Figure 3.

Diaphragmatic pacing improved postictal breathing. Time series data depicting preictal and postictal (A) respiratory rate in breaths per minute, (B) tidal volume in millilitres per breath, and (C) minute ventilation in millilitres per minute plotted as mean ± SEM with single data points for each mouse represented as blue or red dots (ns, P > 0.05, two-tailed t-test; *, P > 0.05, two-tailed two-way ANOVA; n = 8 mice per group, includes fatal and non-fatal trials). (D) Scatter plot depicting the relationship between duration of the first postictal apnoea and motor seizure severity as measured by the E/F ratio among animals that survived the seizure. Seizure severity was positively correlated with the duration of the first apnoea [r(10) = 0.73, P = 0.010].