Figure 3.
Between-group differences in white matter volume and grey matter volume. (A) The white matter volume (WMV) and (B) grey matter volume (GMV) reductions in MDD patients compared with HCs. The colour bar indicates P-value. Representative coronal, sagittal and axial slices of the supra-threshold clusters were overlaid on a MNI152 template. (C) The violin plots depict between-group differences of the GMV values within 12 key regions, where the width indicates subject density, the dashed line indicates average grey matter volume and the scatters indicate subject distribution for each group. Because the raw statistic map was transformed into TFCE values, only for the purpose of display, the GMV values of these regions were derived from the voxel-level statistic map obtained by using two-sample t-test with the threshold of P < 0.001 (uncorrected). HC, healthy control; MDD, major depressive disorder; NACC, nucleus accumbens. For abbreviations of AAL regions, see Supplementary Table 1.