Table 2.

Clusters showed significant grey/white matter volume differences between MDD patients and HCs

Anatomical regiona	Side	MNI coordinatesb			Cluster size	P-value
		x	y	z
GMV
THA	L	−8	−6	4	1112	<0.001
AMYG	R	21	0	−15	353	0.001
HIP	R	18	−9	−15	265	0.001
PHG	L	−20	−26	−18	516	0.002
PHG	R	14	0	−18	407	0.002
THA	R	10	−9	7	328	0.005
STG	R	65	−20	12	2480	0.005
INS	L	−32	24	0	1345	0.005
HES	R	39	−24	9	528	0.005
ORBinf	L	−21	18	−14	583	0.006
PUT	L	−24	17	6	187	0.006
REC	R	2	51	−18	551	0.007
OLF	L	−20	6	−12	391	0.007
SMG	R	56	−33	27	672	0.008
INS	R	39	11	2	2259	0.009
REC	L	0	49	−18	925	0.009
ORBsupmed	R	9	51	−12	768	0.009
ACG	L	−4	35	−9	423	0.009
MTG	R	66	−22	−3	160	0.010
STG	L	−60	−17	9	1731	0.017
MFG	L	−33	50	1	280	0.017
HES	L	−51	−16	10	299	0.018
TPOmid	R	21	12	−36	522	0.019
ORBmid	L	−39	45	0	193	0.019
FFG	R	28	5	−41	687	0.021
SFGdor	L	−16	50	34	808	0.027
MTG	L	−63	−33	2	382	0.035
WMV
THA	R	10	−22	9	613	0.004
THA	L	−6	−15	10	431	0.006
PreCG	R	32	−19	57	1192	0.010
PreCG	L	−28	−22	55	625	0.015
PoCG	L	−26	−40	48	608	0.017
SMA	R	9	−27	58	446	0.017
PCL	R	6	−30	61	330	0.018
PCUN	L	−15	−42	60	244	0.018
DCG	L	−14	−16	45	214	0.021
CAU	R	16	−18	21	397	0.022
IFGoperc	R	36	8	30	128	0.029
SFGdor	R	15	11	54	302	0.030
PoCG	R	30	−27	60	217	0.031
ACG	L	−3	35	−2	180	0.031
STG	R	56	−24	1	862	0.034

GMV, grey matter volume; HC, healthy control; L, left; MDD, major depressive disorder; R, right; WMV, white matter volume.

^a For full names of these abbreviations from AAL atlas, see Supplementary Table 1.

^b The MNI coordinates of the voxel with maximum statistical significance for identified clusters. Each cluster was represented by a coordinate of the peak voxel in this cluster.