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The overall architecture of our proposed system. Serial IHC images with biomarker Ki67 and PHH3 are registered to the H&E slide for each patient. Tumor cells in H&E images are detected, and positive biomarker areas in IHC images are identified. A spatial attention mechanism is introduced to direct system attention to areas enriched with tumor cells of positive Ki67 and PHH3 biomarkers. Finally, a ResNet-34-based deep learning model is trained for pCR prediction
