Figure 1.

Key group A Streptococcus disease syndromes. Colonization of upper respiratory infection and skin is not included. Note this is a simplified figure of the diseases associated with group A Streptococcus. Locally invasive disease and invasive disease can also include bacteremia, meningitis, puerperal sepsis, and necrotizing fasciitis. Toxin-mediated diseases can also include streptococcal toxic shock syndrome. Direct sequelae can also include chronic kidney disease. Figure adapted with permission by Cannon et al [20].