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. 2022 Oct 3;132(19):e160898. doi: 10.1172/JCI160898

Figure 5. Preexisting T cell immunity does not impact NVX-CoV2373 vaccine responses.

Figure 5

(A) Spike-specific AIM+ CD4+ T cells at baseline and after vaccination grouped according to donors with detectable AIM+ CD4+ T cell responses on day 0 (blue dots) or no detectable AIM+ CD4+ T cell responses on day 0 (black dots). Effect of preexisting AIM+ CD4+ T cells on (B) spike-specific AIM+ cTfh cells, (C) spike-specific AIM+ CD8+ T cells, (D) total spike-specific CD4+ T cells and (E) spike-specific CD8+ T cell cytokine production. Dotted line indicates limit of sensitivity for the assay, and was calculated as the geometric mean of all sample DMSO wells multiplied by the geometric SD. Data were analyzed by Mann-Whitney test. Data shown as geometric mean ± geometric SD. *P < 0.05; ***P < 0.001; ****P < 0.0001.