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. 2022 Sep 16;15:974890. doi: 10.3389/fnmol.2022.974890

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Copyright © 2022 DeGiosio, Grubisha, MacDonald, McKinney, Camacho and Sweet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Domains of MAP2 and homology to MAP Tau. (A) Diagram depicting the domains of the four major isoforms of MAP2. Microtubule (MT)-binding repeats are denoted by black rectangles. Note that an additional MT binding repeat (MBR; gray box) is present in the low molecular weight (LMW) isoform MAP2D. Tau is also shown for size comparison. (B) Protein BLAST (https://blast.ncbi.nlm.nih.gov/Blast.cgi) alignment of the C-terminus (highlighted region of MAP2B in A) from MAP2B (Uniprot P11137-1; top) and 2N4R Tau (P10636-8; bottom). The MT-binding repeat sequences for each protein are indicated with solid boxes. The middle row indicates homologous or similar (+) residues. MAP2B S1782 (mentioned in the text) is highlighted in red. Figure generated in Microsoft Powerpoint.