Figure 2.

Hypothesized model of “MAP2opathy”. Genetically- or environmentally-precipitated upstream risk factors are expected to affect MAP2 in a variety of ways, leading to diverse, overlapping cellular consequences. Thick arrows indicate causal relationships established in in vivo models (Harada et al., 2002; Kim et al., 2020; Grubisha et al., 2021). Thin arrows indicate noted correlational relationships (Pettigrew et al., 1996; Guo et al., 2012; Cabrera and Lucas, 2017). Figure generated in Microsoft Powerpoint.