Table 1.
Evidence of MAP2 dysfunction in neuropsychiatric and neurodegenerative disorder.
| Disorder | Region | Finding | References |
|---|---|---|---|
| Schizophrenia | DLPFC | Reduced MAP2-IR intensity | DeGiosio et al. (2019) |
| Lateral intraparietal cortex | Reduced MAP2-IR intensity | DeGiosio et al. (2019) | |
| Primary visual cortex | Reduced MAP2-IR intensity | DeGiosio et al. (2019) | |
| Hippocampus | Qualitative absence of MAP2-IR in subset of subjects | Arnold et al. (1991) and Rosoklija et al. (2005) | |
| Olfactory bulb | Reduced MAP2-IR intensity | Rioux et al. (2004) | |
| DLPFC | Reduced MAP2-IR+ area fraction | Somenarain and Jones (2010) | |
| Anterior cingulate cortex (BA32) | Reduced MAP2-IR+ area fraction | Jones et al. (2002) | |
| Primary auditory cortex | Reduced MAP2-IR intensity | Shelton et al. (2015) and McKinney et al. (2019) | |
| Primary auditory cortex | Increased MAP2 phosphorylation | Grubisha et al. (2021) | |
| Hippocampus | Reduced MAP2-IR by phospho-specific antibody | Cotter et al. (1997) | |
| Corpus callosum | Increased MAP2 phosphorylation | Saia-Cereda et al. (2016) | |
| Autism spectrum disorders | DLPFC | Reduced MAP2-IR+ neurons/dendrites | Mukaetova-Ladinska et al. (2004) |
| Neocortex | Qualitative reduction of MAP2-IR | Kaufmann et al. (1995) | |
| n/a | 2q34 deletion encompasses MAP2 gene and causes Rett-like features | Pescucci et al. (2003) and Westphal et al. (2018) | |
| Mood disorders major depressive/bipolar disorders | Subiculum | Qualitative absence of MAP2-IR in subset of subjects | Rosoklija et al. (2005) |
| DLPFC | Qualitative reduction of MAP2-IR | Kang et al. (2012) | |
| DLPFC | Reduced MAP2 protein | Kang et al. (2012) | |
| DLPFC | Decreased MAP2 phosphorylation at S233, S1031 | Martins-de-Souza et al. (2012) | |
| Various regions | Reduced MAP2 mRNA in males with major depressive disorder | Labonté et al. (2017) | |
| Anterior cingulate cortex | Reduced MAP2 protein | Föcking et al. (2016) | |
| Huntington’s Disease | Striatum | Altered MAP2 splicing | Cabrera and Lucas (2017) |
| Striatum | Qualitative loss of dendritic MAP2-IR | Cabrera and Lucas (2017) | |
| DLPFC | Reduced MAP2-IR+ area fraction | Somenarain and Jones (2010) | |
| Prion Disease | n/a brain homogenate | Reduced MAP2 protein (coincident with increase in calpain) | Guo et al. (2012) |
| Tauopathy | n/a | MAP2 phosphopeptides (T350, S1702, S1706) identified in purified NFTs | Rudrabhatla et al. (2011) |
Evidence of MAP2 dysfunction in these disorders includes various irregularities in MAP2 immunoreactivity, expression level, and/or modification.