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. 2022 Apr 5;29(10):1982–1995. doi: 10.1038/s41418-022-00990-5

Fig. 5. PRMT4 overexpression promotes DOX-induced ferroptosis in vivo.

Fig. 5

AAV-PRMT4 or AAV-NC were applied via tail vein injection, 2 weeks later, DOX was injected intraperitoneally, then hearts were harvested for analysis on day 7. a Representative DHE staining images were shown; b Relative ROS intensity was statistically analyzed, *P < 0.001, #P < 0.001; c–e Quantitative analysis of GSH level (e, *P < 0.01, #P < 0.001), MDA level (f, *P < 0.001, #P < 0.001), and GPX4 activity (g, *P < 0.001, #P < 0.001); f Representative western blots of PRMT4, NCOA4, and GPX4 were shown; g–i Quantitative analysis of the protein level of PRMT4 (g, *P < 0.001, #P < 0.001, $P < 0.001), NCOA4 (h, *P < 0.001, #P < 0.001), and GPX4 (i, *P < 0.05, #P < 0.001).