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. 2022 Feb 25;43(10):2624–2635. doi: 10.1038/s41401-022-00885-8

Fig. 2. MAPK signaling contributes to the direct cardiomyocyte protection of Dapa.

Fig. 2

H9c2 cells were pretreated with Dapa, and were then stimulated with PA for 24 h. Samples were isolated using TRIzol, and transcriptome sequencing was conducted. a PCA analysis of the sequencing results. b Venn diagram of differential genes in Ctrl VS PA, and PA VS PA + Dapa. c Panther pathway enrichment analysis of 70 intersecting genes. d PPI hub-proteins analysis of 70 intersecting genes. e TRRUST transcription analysis of 70 intersecting genes. Dotted lines represented P = 0.05. Black column showed significant changed items.