Fig. 1. Sotagliflozin improves cell viability in skeletal muscle cells under hyperglycemia.

Total cell number of C2C12 cells treated with different doses of sotagliflozin and cultured under hyperglycemia for 48 h (a) or 72 h (b) (n = 3). c, d Effect of different dosages of sotagliflozin treatment on C2C12 cells viability as examined by colony formation assay. Representative images (c) and quantification results (d; n = 4) were shown. Cells cultured under normoglycemia were used as controls. Data were presented as mean ± SD. NG normoglycemia, HG + Sota hyperglycemia + sotagliflozin, NS not significant; **P < 0.01; ***P < 0.001.