Fig. 6.

Macroscopic appearance, histology, and clinical chemistry of kidney tissue. Gross pathology (A) and histopathology (B) with hematoxylin and eosin staining of tissue sections of the kidneys of wild-type, heterozygous, and homozygous albumin knockout mice 24 h after OTA or vehicle treatment. Scale bars: 10 µm. C Plasma concentrations of creatinine and urea nitrogen in untreated and OTA intoxicated wild-type and albumin knockout (heterozygous and homozygous) mice; n = 5 mice per group. D CD45 immunostaining in the kidney tissue showing no obvious immune cell infiltration after OTA administration neither in the wild-type nor in the albumin knockout mice; scale bars: 50 µm. Representative images of 5 mice per group are shown