TABLE 1.
Summary of the variables assessed in the 14 Lothian birth cohort 1936 participants
| Variable | Mean | SD |
|---|---|---|
| Sex (% female) | 35.71 | ‐ |
| Age at death (years) | 80.33 | 1.56 |
| Age at last blood draw | 77.88 | 1.67 |
| Brain | ||
| DNAm CRP score | −0.014 | 6.1 × 10−4 |
| DNAm IL‐6 score | 0.016 | 0.0045 |
| AgeAccelCortical | −0.52 | 6.12 |
| AgeAccelGrim | −0.31 | 2.32 |
| AgeAccelPheno | 0.053 | 5.71 |
| IEAA | −0.049 | 3.97 |
| EEAA | −0.55 | 3.38 |
| CD68 burden (%) | 0.34 | 0.38 |
| Blood | ||
| DNAm CRP score | −0.014 | 1.2 × 10−3 |
| DNAm IL‐6 score | 0.020 | 6.5 × 10−3 |
| AgeAccelGrim | 6.68 | 6.53 |
| AgeAccelPheno | 3.23 | 8.48 |
| IEAA | 1.23 | 5.62 |
| EEAA | 2.99 | 11.20 |
Note: The brain variables refer to the mean across all five regions.
Abbreviations: CD68, Cluster of Differentiation 68 (microglial burden); CRP, C‐reactive protein; DNAm, DNA methylation; EEAA, extrinsic epigenetic age acceleration; IEAA, intrinsic epigenetic age acceleration; IL‐6, interleukin‐6.