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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Pharmacol Ther. 2022 Apr 1;239:108181. doi: 10.1016/j.pharmthera.2022.108181

Figure 1.

Figure 1.

Major biosynthetic pathways of oxylipin production and the bioactive effects of oxylipins on inflammation

Please note that after aspirin-acetylation, COX acts similar to 15-LOX to produce pro-resolving mediators shown (e.g., D-series resolvins, maresins) and not shown (e.g., protectins, neuroprotectins) in the figure.

Abbreviations: 8-isoprostane, 8-iso-prostaglandin-F2α; AA, arachidonic acid; COX, cyclooxygenase; CYP, cytochrome P450; DHA, docosahexaenoic acid; DHET, dihydroxy-eicosatrienoic acid; DiHDPA, dihydroxy-docosapentaenoic acid; DiHETE, dihydroxy-eicosatetraenoic acid; DiHOME, dihydroxy-octadecenoic acid; EET, epoxyeicosatrienoic acid; EPA, eicosapentaenoic acid; EpDPE, epoxy-docosapentaenoic acid; EpETE, epoxy-eicosatetraenoic acid; EpOME, epoxy-octadecenoic acid; HETE, hydroxyeicosatetraenoic acid; HODE, hydroxy-octadecadienoic acid; LA, linoleic acid; LOX, lipoxygenase; LT, leukotriene; LX, lipoxin; PG, prostaglandin; PGI, prostacyclin; TX, thromboxane