Table 2:

Uncertainty and Mental Health (Overall and Stratified by Disease)

	Overall	AAV	IgG4-RD	SSc	P-Value
N	132	41	61	30
MUIS n (%)
Median, IQR	55.0 [48.0, 62.0]	55.0 [48.0, 62.0]	53.0 [48.0, 58.0]	59.0 [55.0, 66.0]	0.002
Q1 (22–44)	21 (15.9)	8 (19.5)	12 (19.7)	1 (3.3)
Q2 (44–66)	97 (73.5)	25 (61.0)	48 (78.7)	24 (80.0)
Q3 (66–88)	13 (9.8)	7 (17.1)	1 (1.6)	5 (16.7)
Q4 (88–110)	1 (0.8)	1 (2.4)	0 (0.0)	0 (0.0)
Missing	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
PHQ-8 n (%)
Median, IQR	3.0 [1.0, 6.0]	4.0 [2.0, 9.0]	2.5 [0.5, 5.0]	3.0 [1.0, 7.0]	0.03
Minimal (0–4)	84 (63.6)	21 (51.2)	44 (72.1)	19 (63.3)	0.10*
Mild (5–9)	31 (23.5)	10 (24.4)	13 (21.3)	8 (26.7)
Moderate (10–14)	5 (3.8)	4 (9.8)	0 (0.0)	1 (3.4)
Moderately Severe (15–19)	5 (3.8)	2 (4.9)	2 (3.3)	1 (3.4)
Severe (20–24)	5 (3.8)	4 (9.8)	1 (1.6)	0 (0.0)
Missing	2 (1.5)	0 (0.0)	1 (1.6)	1 (3.4)
GAD-7 n (%)
Median, IQR	2.0 [0.0, 5.5]	5.0 [2.0, 8.0]	1.0 [0.0, 4.0]	2.0 [0.0, 5.0]	0.002
Minimal (0–4)	90 (68.2)	20 (48.8)	48 (78.7)	22 (73.3)	0.005*
Mild (5–9)	34 (25.8)	16 (39.0)	11 (18.0)	7 (23.3)
Moderate (10–14)	6 (4.5)	4 (9.8)	1 (1.6)	1 (3.3)
Severe (15–21)	2 (1.5)	1 (2.4)	1 (1.6)	0 (0.0)
Missing	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
SIP n (%)
Median, IQR	1.0 [0.0, 6.0]	2.0 [0.0, 6.0]	1.0 [0.0, 7.0]	1.0 [0.0, 5.0]	0.60
Q1 (0–5)	92 (69.7)	27 (65.9)	41 (67.2)	24 (80.0)
Q2 (6–11)	34 (25.8)	12 (29.3)	16 (26.2)	6 (20.0)
Q3 (12–16)	6 (4.5)	2 (4.9)	4 (6.6)	0 (0.0)
Q4 (17–22)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Missing	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)

AAV: ANCA-Associated Vasculitis; IgG4-RD: IgG4-Related Disease; SSc: Systemic Sclerosis; MUIS: Mishel Uncertainty in Illness Scale; PHQ-8: Patient Health Questionnaire depression scale; GAD-7: General Anxiety Disorder; SIP: Sickness Impact Profile

^*P-value compares the proportion of patients with at least mild depression or anxiety across the three disease groups.