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. 2022 Mar 8;43(10):2573–2584. doi: 10.1038/s41401-022-00875-w

Fig. 3. ELA-21 inhibited proliferation in SHR-VSMCs and Ang II-stimulated WKY-VSMCs.

Fig. 3

The VSMC proliferation was evaluated with EdU-positive cells, CCK-8 kits and PCNA expression. a, b EdU-positive cells; c, e CCK-8 kits; d, f mRNA level of PCNA; g, h protein level of PCNA. For SHR-VSMCs, the cells were treated with ELA-21 (200 nM) for 24 h. For WKY-VSMCs, the cells were treated with ELA-21 (200 nM) for 2 h followed by Ang II (100 nM) for 24 h. n = 6 per group in a–c and e; n = 4 per group in d, f–h. Values are mean ± SEM. *P < 0.05.