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. 2022 Mar 8;43(10):2573–2584. doi: 10.1038/s41401-022-00875-w

Fig. 4. ELA-21 infusion for 4 weeks attenuated vascular remodeling and lowered blood pressure in SHRs.

Fig. 4

a ELA level in plasma determined by ELISA; b, c systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) in a conscious state; d representative photographs of aorta and mesenteric artery (MA) by hematoxylin and eosin staining and Masson’s staining; e–h media thickness, lumen diameter, ratio of media thickness to lumen diameter and intima-media thickness (IMT) in aorta and MA. Arrows indicate the internal elastic lamina (IEL); Arrowhead denotes the endothelial cells. IMT is defined as the distance from endothelium to media-adventitia transition. n = 6 per group. Values are mean ± SEM. *P < 0.05.