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. 2022 Mar 8;43(10):2573–2584. doi: 10.1038/s41401-022-00875-w

Fig. 8. ELA-21 inhibited PI3K/Akt pathway and activated Nrf2 through APJ receptor in SHR-VSMCs.

Fig. 8

a Phosphoinositide3-kinase (PI3K) p85α and Akt phosphorylation. b nuclear Nrf2 expression determining by immunofluorescent staining. APJ receptor antagonist F13A (1 μM) was added into the medium 0.5 h before administration of ELA-21 (200 nM) in SHR-VSMCs. The measurements were made 24 h after ELA-21 treatment. n = 4 in a, and n = 6 in b. Values are mean ± SEM. *P < 0.05.