Fig. 1. GWAS Models for Problematic Alcohol Use and Externalizing.

Univariate (A) and multivariate (B) GWAS models for problematic alcohol use and externalizing. The SNP associations with the yellow box labeled ALCP are referred to herein as “ALCP-total” (original problematic alcohol use), the SNP associations with the purple circle are referred to herein as “EXT” (shared risk towards externalizing), and the SNP associations with the teal circle are referred to herein as “ALCP-specific” (problematic alcohol user-specific).