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. 2022 Sep 30;12:420. doi: 10.1038/s41398-022-02171-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Panel (A) presents the genetic correlations (r_g) and 95% CI between problematic alcohol use (ALCP-total, yellow dots), problematic alcohol use-specific (ALCP-specific, teal dots), and selected traits significantly correlated with ALCP-total (after correcting for an FDR of 5%, Supplementary Table 2 reports all preregistered genetic correlations). Asterisks (*) in Panel (A) represent genetic correlations for ALCP-specific that differ significantly from those with ALCP-total. Panel (B) presents changes in point estimates for genetic correlations from ALCP-total to ALCP-specific. In Panel (B), asterisks represent genetic correlations for ALCP-specific that are still significant (after correcting for an FDR of 5%).