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. 2022 Sep 30;12:16396. doi: 10.1038/s41598-022-20657-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Concentration of secreted proinflammatory cytokines in the basal media of sham exposed and HTP-smoke exposed bro-ALI model. IFNγ: interferon gamma; IL: interleukin; TNFα: tumor necrosis factor alpha. Data are shown as medians and interquartile ranges. n = 6 per exposure condition; non-parametric statistical analysis (Wilcoxon signed rank test); *Significance: p < 0.05. bro-ALI: bronchial mucosa model at air–liquid interface; HTP: heated tobacco product.