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. 2022 Sep 30;12:16453. doi: 10.1038/s41598-022-20509-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The anti-leishmanial activity of CA, capric acid and lauric acid after 48 h treatment against L. donovani promastigotes in vitro (A) and against intracellular amastigotes ex vivo (B). Further, the anti-leishmanial activity of caprylic acid methyl ester (1m-CAE), 4-methyl caprylic acid (4m-CA), 8-amino caprylic acid and valproic acid were compared with caprylic acid for both promastigotes (C) and amastigotes (D) at the same time interval. Structure of CA and their analogues used in this study (E). Note: *P < 0.05; **0.05 < P < 0.01; ***0.01 < P < 0.001.