Figure 6.

Protein and metabolite alteration in glycolysis, TCA cycle, mitochondria respiration, and aspartate/glutamate to pyruvate shunting pathways in M1-Mɸ versus M2-Mɸs.A, STRING network of proteins detected by quantitative proteomics in glycolysis. Red color: proteins are upregulated in M2-MФ; blue color: proteins are upregulated in M1-MФ. LOG₂ (fold changes) of protein expression (M2-MФ/M1-MФ) are represented by the color key on the bottom. B, STRING network of proteins detected by quantitative proteomics in mitochondria respiratory chain. C, STRING network of proteins detected by quantitative proteomics in TCA cycle, pyruvate, and aspartate/glutamate pathways. D, concentrations of asparagine, aspartic acid, glutamine, glutamic acid, acetylated aspartic acid, acetylated glutamic acid, and acetylated ornithine measured by LC/MS. E, heat map of (D). TCA, tricarboxylic acid.