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. 2022 Sep 14;66:101602. doi: 10.1016/j.molmet.2022.101602

Figure 4.

Figure 4

Effect of PFOA and GenX on hepatic metabolism in wildtype and PPARα−/−mice. (A) Glycogen concentrations in liver. (B) Triglyceride concentrations in liver. (C) H&E staining of representative liver sections (20× magnification). (D) Hepatic gene expression of Cd326, Cyp4a14, Ehhadh, Lpl, and Fgf21. Data are normalized to cyclophilin and expressed relative to wildtype control. Graphs are presented as mean ± SEM (n = 9–12 mice per group). Asterisks indicate significant differences between treatment vs control (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 ∗∗∗∗p < 0.0001). Hashtags indicate significant differences between wildtype vs PPARα−/− mice within one treatment group (#p < 0.05, ##p < 0.01, ###p < 0.001, ####p < 0.0001).