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A working model illuminating MEF2D-IRF8 circuit in AML
Oncogenic events (such as KMT2A-r and FLT3ITD + NPM1c) (Yun et al., 2021) can lead to activation and addiction to the MEF2D-IRF8 transcriptional circuit in AML. IRF8-PU.1 complex and MEF2D cooperatively maintain PU.1/MEIS1 co-regulated gene expression (Zhou et al., 2014) and AML state.
