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. 2022 Sep 16;25(10):105150. doi: 10.1016/j.isci.2022.105150

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Transcriptome analysis of S. aureus-infected ALI-skin organoids

(A) The differentially expressed genes (DEGs) are visualized. A heatmap of the one-way hierarchical clustering using Z score for normalized value (log2 based) (4,255 genes satisfying fc2 and raw. P) is shown. Genes in untreated control (in red) and genes in S. aureus-infected (blue) ALI-skin organoids are shown.

(B) The DEGs were classified based on the top 10 terms of GO functional analysis of biological processes (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001).

(C and D) Downregulated genes involved in keratinocyte differentiation genes (C) and in epidermal barrier functional genes (D) by S. aureus infection are shown.

(E) Upregulated genes for the skin organoid derived inflammatory markers by S. aureus infection are shown.