Fig. 3.

Associations between NOX4 and the type of atherosclerotic lesions obtained from asymptomatic and symptomatic patients. (A–B), Atherosclerotic plaques were scored according to the AHA classification of human carotid atherosclerotic lesions. Type V are fibroatheroma; type VI are atheroma with a thrombus and intramural hemorrhage; type VII atheroma with a fibrous cap and calcified nodules; type VIII reflects the fibrous type. NOX4 expression was analyzed by qPCR and normalized to an internal control (=1). Data are presented as scatter dot plots where the horizontal line depicts the median. The number of patients with their plaque NOX4 expression in the corresponding AHA plaque stage is given below each figure. Statistical significant outliers were detected by Grubb's outlier test. In asymptomatic disease, one patient from type V and VI and one from type VI and VII in symptomatic disease, respectively, was omitted from the analysis. Data were compared using Kruskal-Wallis and Dunn's multiple comparison test.