Fig. 7.
Correlation between NOX4 and endothelial cell marker CD31 in atherosclerotic plaques obtained from patients with asymptomatic and symptomatic carotid artery stenosis. (A) Endothelial cells were stained using a specific antibody against CD31 and positive areas were quantified and set in relation to the total plaque area. (A), Data are presented as a scatter dot plot where the horizontal line depicts the median. Data were compared using the Mann-Whitney-U test. *p ≤ 0.05. (B–C) Spearman's correlation (rS) between plaque NOX4 and CD31 positive areas in asymptomatic and symptomatic disease. (D) Representative slides for CD31 immunohistochemistry in plaques from patients with asymptomatic and symptomatic carotid artery disease. Scale bar upper picture: 2.5 mm. Scale bar lower picture: 300 μm.