Fig. 8.
Correlation between NOX4 and macrophage content in atherosclerotic plaques obtained from patients with asymptomatic and symptomatic carotid artery stenosis (A) Macrophages were stained using a specific antibody against CD68 and positive areas were quantified and set in relation to the total plaque area. (A) Data are presented as a scatter dot plot where the horizontal line depicts the median. Data were compared using the Mann-Whitney-U test. *p ≤ 0.05. (B–C), Spearman's correlation (rS) between plaque NOX4 expression and macrophages in asymptomatic and symptomatic disease. (D) Representative slides for CD68 immunohistochemistry in plaques from patients with asymptomatic and symptomatic carotid artery disease. Scale bar upper picture: 2.5 mm. Scale bar lower picture: 300 μm.