Table 4.

NOX4 expression and prescription of statins and insulin. NOX4 expression was analyzed by qPCR and data were normalized to an internal control (=1). Expression was divided into low and high, depending on the mean. Data were analyzed by multivariate logistic regression and multiple comparison using a high NOX4 as a variable in response to statin and insulin prescription. Adjusted values were obtained by pairwise comparison of each variable listed in the table with the outcome of high NOX4 expression. The odds refers to the chance for increased NOX4 expression if the patient received (1) or did not receive (0) statins or insulin or a combination of both.

Statin	Insulin	Odds of high NOX4 vs. low NOX4	p-value
0	1	0.11 [0.02, 0.54]	0.007
1	0	0.31 [0.18, 0.53]	<0.001
0	1	1.47 [0.27, 8.10]	0.661
1	1	4.04 [0.96, 17.07]	0.057