Table 3.

Estimates of the treatment effects (${\beta }_t$ and $\beta 0_t$) on the primary outcome at time t, test statistics (Z and Z0) and information accrual (I), at each interim analysis and the study end, for each RCT; where $Z={\beta }_t/\mathrm{sd}({\beta }_t)$, $Z0=\beta 0_t/\mathrm{sd}(\beta 0_t)$ and $I=1/\text{var}({\beta }_t)$ and $I0=1/\text{var}(\beta 0_t)$. The primary outcome time-point t and the expected information $I^{\ast }$, to trigger each interim analysis, are shown for each RCT

RCT	Early and primary			Primary only
Interim	${\beta }_t$	Z	I	$\beta 0_t$	Z0	I0
WAT ($t=12m$ and $I^{\ast }=$ 0.150 and 0.321)
1	4.30	1.68	0.152	6.80	1.78	0.068
End	2.18	1.16	0.283	2.23	1.18	0.278
DRAFFT ($t=12m$ and $I^{\ast }=$ 0.073 and 0.219)
1	1.41	0.40	0.080	4.39	0.89	0.041
End	1.51	0.94	0.387	1.37	0.85	0.384
WOLLF ($t=12m$ and $I^{\ast }=$ 0.025, 0.050, 0.075 and 0.165)
1	-0.36	-0.06	0.025	-1.79	-0.22	0.016
2	-2.76	-0.62	0.051	4.11	0.73	0.032
3	0.19	0.05	0.075	2.16	0.51	0.056
End	-3.65	-1.38	0.143	-3.14	-1.16	0.137
FASHION ($t=12m$ and $I^{\ast }=$ 0.025, 0.050 and 0.127)
1	3.60	0.58	0.026	7.08	1.08	0.023
2	6.50	1.50	0.053	6.77	1.48	0.048
End	8.74	2.99	0.117	9.08	3.09	0.116
CSAW ($t=6m$ and $I^{\ast }=$ 0.123, 0.247 and 0.525)
1	1.42	0.52	0.134	1.42	0.52	0.134
2	2.17	1.08	0.249	2.17	1.08	0.249
End	3.31	1.89	0.325	3.31	1.89	0.325
FIXDT ($t=6m$ and $I^{\ast }=$ 0.036, 0.071 and 0.165)
1	1.14	0.22	0.037	2.29	0.41	0.033
2	-2.85	-0.76	0.072	-0.52	-0.13	0.066
End	-4.27	-1.51	0.125	-3.97	-1.39	0.124