Table 4.

Estimates of correlations between early and primary outcomes (${\rho }_{s,t}$) and standard deviations ($\sigma$), at each interim analysis and the study end, for each RCT; the expected correlations were ${\rho }_{s,s^{\prime }}^{\ast }=0.5$ for all pairs of outcomes for all RCTs and the primary outcome time-point t and expected standard deviation (${\sigma }_t^{\ast }$) are shown for each RCT

RCT	Correlations ($\rho$)			Standard deviations ($\sigma$)
Interim	${\rho }_{1,t}$	${\rho }_{2,t}$	${\rho }_{3,t}$	${\sigma }_1$	${\sigma }_2$	${\sigma }_3$	${\sigma }_t$
WAT (FU at 6w, 3m, 6m and $t=12m$ and ${\sigma }_t^{\ast }=9$)
1	0.60	0.71	0.50	9.9	10.4	9.7	5.6
End	0.59	0.72	0.80	10.1	9.8	8.9	10.4
DRAFFT (FU at 3m, 6m and $t=12m$ and ${\sigma }_t^{\ast }=20$)
1	0.78	0.72	-	22.3	17.5	-	13.5
End	0.61	0.73	-	22.6	18.2	-	16.6
WOLLF (FU at 3m, 6m, 9m and $t=12m$ and ${\sigma }_t^{\ast }=25$)
1	0.59	0.77	0.88	22.6	23.5	26.7	25.7
2	0.58	0.78	0.89	22.1	23.9	24.7	24.7
3	0.48	0.71	0.82	21.1	23.6	25.2	26.4
End	0.58	0.73	0.74	21.3	23.9	25.6	26.2
FASHION (FU at 6m and $t=12m$ and ${\sigma }_t^{\ast }=20$)
1	0.56	-	-	22.9	-	-	25.8
2	0.56	-	-	23.9	-	-	27.3
End	0.57	-	-	24.1	-	-	26.3
CSAW (FU at $t=6m$ and ${\sigma }_t^{\ast }=9$)
1	-	-	-	-	-	-	12.2
2	-	-	-	-	-	-	11.7
End	-	-	-	-	-	-	11.8
FIXDT (FU at 3m and $t=6m$ and ${\sigma }_t^{\ast }=20$)
1	0.61	-	-	20.1	-	-	24.6
2	0.65	-	-	20.1	-	-	23.7
End	0.65	-	-	20.0	-	-	24.1