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. 2022 Sep 28;63(10):20. doi: 10.1167/iovs.63.10.20

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Figure 4. — Downregulation of METTL3 expression attenuates the inflammatory response and improves FK clinical scores. (A) Slit-lamp biomicrographs of mouse eyes 5 days after infection after pretreatment with AAV-sh-METTL3. (B) Histopathological observation of mouse corneal H&E staining. Scale bar: 50 µm. (C) Clinical scores showed that the inflammatory response was significantly reduced in the AAV-sh-METTL3 group compared with the FS group. (D–F) The mRNA levels of IL-1β, IL-6, and TNF-α were significantly lower in the AAV-sh-METTL3 group than in the FS group. (G) Number of corneal fungal colonies in each group of mice. (H–K) Protein levels of IL-1β, IL-6, and TNF-α were significantly lower in the AAV-sh-METTL3 group than in the FS group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; n = 6.