Table 2.

Experimental matrix and data of the DoE approach

No	MOI	TOI	pH	Titer (IFU/mL)			Virus input–output ratio
				1 dpi	2 dpi	3 dpi	1 dpi	2 dpi	3 dpi
1	1	2	6.9	1.5E+08	1.5E+09	4.4E+09	75	754	2211
2	5	2	7.2	6.6E+07	1.9E+09	4.4E+09	6	179	415
3	10	2	7.2	1.3E+08	2.4E+09	4.6E+09	6	115	220
4	15	2	6.9	7.0E+08	3.7E+09	2.5E+09	22	117	79
5	1	5	7.2	1.6E+07	3.0E+09	6.4E+09	4	687	1465
6	5	5	7.2	5.1E+07	6.5E+09	6.2E+09	2	287	274
7	10	5	6.9	1.5E+09	5.8E+09	4.4E+09	35	136	103
8	15	7	7.2	5.0E+08	1.4E+10	6.2E+09	5	139	61
9	1	7	7.2	5.8E+07	4.5E+09	9.3E+09	8	643	1329
10	5	7	6.9	2.2E+09	5.0E+09	3.4E+09	57	130	89
11	10	10	7.2	5.1E+08	9.8E+09	7.1E+09	5	100	72
12	15	10	6.9	3.5E+09	5.0E+09	2.0E+09	21	30	12
13	1	10	6.9	7.9E+08	4.2E+09	3.3E+09	72	384	301
14	15	7	7.2	6.6E+08	1.5E+10	9.9E+09	6	132	87
15	15	10	6.9	3.1E+09	5.4E+09	1.9E+09	18	32	11
16	10	2	7.2	1.4E+08	3.4E+09	6.0E+09	6	148	261