Fig. 4.

A Effects of mosliciguat after inhaled application under thromboxane A2-induced PH in minipigs compared with iloprost inhalation as clinical reference. B Observed (symbols) and predicted (lines) PAP (mean) values after administration of 0.15, 0.5, 1.5, and 5 µg/kg mosliciguat (lung-deposited doses; figure shows inhalation doses) to minipigs (7-min inhalation as liquid aerosol). Data are mean ± SEM (n = 3–4). PAP (mean) reduction of 5% indicated as straight dotted line. BP mean blood pressure, PH pulmonary hypertension, PAP mean pulmonary arterial pressure, SEM standard error of the mean