Fig. 9.

Mosliciguat capacity to decrease maximal hypoxic PAP (mean) (positive treatment effect) and AUC SaO₂ (unwanted desaturation effect) based on effects of representative cycles (n = 4 animals); data are mean ± SEM (n = 4). Mosliciguat inhaled (100 µg/kg nominal dose); intravenous 30 and 100 µg/kg. AUC SaO₂ area under the SaO₂ curve, PAP mean pulmonary arterial pressure, SaO₂ arterial oxygen saturation of hemoglobin, SEM standard error of the mean, VQ ventilation/perfusion