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. 2022 Aug 16;27(10):874–883. doi: 10.1093/oncolo/oyac150

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 2. — Age-adjusted incidence of CCA, iCCA, eCCA (A), CUP (B); incidence of CCA by age (C), sex (D), and race (E); annual mortality rates for CCA, iCCA, eCCA, and CUP (F) from 2001 to 2017. Incidence was determined per 100 000 p-y and age-adjusted to the US standard population of 2000. Also shown in panel B is the incremental difference between age-adjusted iCCA and CUP incidences from 2001 to 2017. Note that interpretation of trends in CCA incidence in the American Indian/Alaska Native cohort is limited by the correspondingly small sample size (n = 327).

Abbreviations: CCA, cholangiocarcinoma; CUP, cancer of unknown primary; eCCA, extrahepatic cholangiocarcinoma; iCCA, intrahepatic cholangiocarcinoma; p-y, person-year.