Table 4.
Annual percentage change in incidence-based mortality due to CCA, iCCA, eCCA, and CUP from 2001-2017.
| Annual percentage change (95% CI), per 100 000 p-y | ||||
|---|---|---|---|---|
| CCA (N = 40 030) | iCCA (N = 13 174) | eCCA (N = 26 821) | CUP (N = 32 980) | |
| 2001-2017 | 2.90 (2.57-3.23)a | 6.21 (5.18-7.25)a | 1.33 (0.48-2.19)a | −4.42 (−4.71 to −4.13)a |
| Age, years | ||||
| 18-44 | 3.86 (2.36-5.38)a | 7.90 (5.58–10.27)a | 1.27 (−0.40 to 2.98) | ND |
| 45-64 | 3.42 (2.89-3.96)a | 7.55 (6.70-8.40)a | 1.17 (0.59-1.76)a | ND |
| 65-84 | 2.51 (2.29–2.74)a | 6.81 (5.74-7.89)a | 0.68 (0.29-1.07)a | ND |
| ≥85 | −0.17 (−0.83 to 0.49) | 3.94 (2.49-5.42)a | −1.62 (−2.50 to −0.74)a | ND |
| 2001-2006 | 4.86 (2.28-7.52)a | 0.02 (−5.18 to 5.50) | 6.71 (2.01-11.62)a | −4.78 (−7.19 to −2.3)a |
| 2007-2012 | 2.04 (0.26-3.84)a | 6.92 (4.84-9.05)a | 0.04 (−2.59 to 2.74) | −4.44 (−6.45 to −2.38)a |
| 2013-2017 | 2.38 (1.67-3.09)a | 10.49 (7.57-13.50)a | −2.42 (−3.43 to −0.45)a | −3.81 (−5.44 to −2.16)a |
Significant annual percentage changes. Changes were deemed significant if the lower and upper 95% CIs were of same sign, otherwise the change was considered not significant.
Abbreviations: CCA, cholangiocarcinoma; CI, confidence interval; CUP, cancer of unknown primary; eCCA, extrahepatic cholangiocarcinoma; iCCA, intrahepatic cholangiocarcinoma; ND, not determined.