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. 2022 Sep 22;2022:2223957. doi: 10.1155/2022/2223957

Figure 1.

Figure 1

SKQ1 treatment ameliorates CDDP-induced AKI. (a) Chemical structure of SKQ1 (Visomitin). Molecular weight, 617.6; molecular formula, C36H42BrO2P. (b) SCr and (c) BUN levels of mice treated with CDDP i.p. or cotreated with various doses of SKQ1. (d) Renal microstructure upon PAS staining and renal tubular injury scores computed for all mouse groups. (e) Representative protein levels of the renal biomarkers KIM-1 and NGAL for all four groups were quantified with ImageJ (NIH, USA). The data are expressed as mean ± SD (n = 6). CDDP: cisplatin; ns: not significant. ∗∗∗∗P < 0.0001, ∗∗∗P < 0.001, and ∗P < 0.05 (by one-way ANOVA for (b–d), t-test for (e)).