Table 2.

Univariate and multivariate analysis of APLN and other clinicopathological factors of LGG for OS in TCGA dataset.

Parameters	Univariate analysis				Multivariate analysis
	HR	95% CI		p	HR	95% CI		p
Age >50 vs. ≤50	3.523	2.459	5.049	≤0.001	3.775	2.472	5.766	≤0.001
Gender Female vs. male	1.143	0.810	1.614	0.446
Headache history Yes vs. no	0.849	0.582	1.240	0.397
Motor movement Yes vs. no	1.368	0.888	2.106	0.155	1.347	0.865	2.100	0.188
Radiation therapy Yes vs. no	1.840	1.205	2.810	0.005	0.976	0.598	1.594	0.923
Neoplasm histologic grade, G3 vs. G1/G2	3.354	2.298	4.895	≤0.001	3.175	1.966	5.128	≤0.001
Seizure history Yes vs. no	0.868	0.608	1.239	0.435
Histology type OD vs. AC/OA	0.680	0.474	0.975	0.036	0.559	0.366	0.854	0.007
Sample type PT vs. RT	1.118	0.544	2.297	0.762
Targeted molecular therapy, yes vs. no	1.383	0.951	2.010	0.090	0.812	0.515	1.280	0.370
APLN expression High vs. low	2.064	1.425	2.990	≤0.001	1.971	1.294	3.002	0.002

Notes: AC: astrocytoma; OA: oligoastrocytoma; OD: oligodendroglioma; PT: primary tumor; and RT: recurrent tumor.