Table 2.
25 potential therapeutic targets of TFDC for GA.
| No. | Target | Symbol | Entrez ID |
|---|---|---|---|
| 1 | 72 kDa type IV collagenase | MMP2 | 4,313 |
| 2 | Plasminogen activator inhibitor 1 | SERPINE1 | 5,054 |
| 3 | Mitogen-activated protein kinase 14 | MAPK14 | 1,432 |
| 4 | Urokinase-type plasminogen activator | PLAU | 5,328 |
| 5 | ATP-binding cassette sub-family G member 2 | ABCG2 | 9,429 |
| 6 | Heme oxygenase 1 | HMOX1 | 3,162 |
| 7 | Nitric oxide synthase, inducible | NOS2 | 4,843 |
| 8 | Stromelysin-1 | MMP3 | 4,314 |
| 9 | Cytosolic phospholipase A2 | PLA2G4A | 5,321 |
| 10 | Mitogen-activated protein kinase 1 | MAPK1 | 5,594 |
| 11 | Prostaglandin G/H synthase 2 | PTGS2 | 5,743 |
| 12 | C-X-C motif chemokine 2 | CXCL2 | 2,920 |
| 13 | Interleukin-1 beta | IL1B | 3,553 |
| 14 | Amine oxidase [flavin-containing] A | MAOA | 4,128 |
| 15 | Prostaglandin G/H synthase 1 | PTGS1 | 5,742 |
| 16 | 5-Hydroxytryptamine receptor 3A | HTR3A | 3,359 |
| 17 | Peroxisome proliferator activated receptor gamma | PPARG | 5,468 |
| 18 | C-reactive protein | CRP | 1,401 |
| 19 | C–C motif chemokine 2 | CCL2 | 6,347 |
| 20 | Transcription factor p65 | RELA | 5,970 |
| 21 | Interleukin-6 | IL6 | 3,569 |
| 22 | Sodium-dependent dopamine transporter | SLC6A3 | 6,531 |
| 23 | Nuclear factor erythroid 2-related factor 2 | NFE2L2 | 4,780 |
| 24 | Matrix metalloproteinase-9 | MMP9 | 4,318 |
| 25 | Monocyte differentiation antigen CD14 | CD14 | 929 |