Table 2.
Bidirectional effects of genetic liability to ADHD on Alzheimer’s disease.
| Causal effect estimates | |||||
|---|---|---|---|---|---|
| No. SNPs | OR | 95% CI | P-value | Q p-value | |
| ADHD on Alzheimer’s disease | |||||
| IVW | 10 | 1.00 | 0.98, 1.02 | 0.39 | 0.68 |
| MR-Egger | |||||
| Intercept | 10 | 0.99 | 0.99, 1.00 | 0.91 | – |
| Slope | 10 | 1.01 | 0.92, 1.11 | 0.76 | 0.58 |
| Weighted median | 10 | 1.01 | 0.99,1.04 | 0.17 | – |
| Alzheimer’s disease on ADHD | |||||
| IVW | 31 | 1.12 | 0.86, 1.44 | 0.37 | 0.10 |
| MR-Egger | |||||
| Intercept | 31 | 0.99 | 0.98, 1.01 | 0.97 | – |
| Slope | 31 | 1.12 | 0.77, 1.64 | 0.53 | 0.86 |
| Weighted median | 31 | 1.12 | 0.81,1.56 | 0.47 | – |
IVW inverse-variance weighted, SNP single nucleotide polymorphism, OR odds ratio, CI confidence Intervals. Results are presented per log odds ratio increase of the exposure of interest.