Table 3.
Direct causal effects of genetic liability to ADHD and on Alzheimer’s disease, independent of (A) Educational Attainment (B) Intelligence (IQ).
| Causal effect estimates | ||||
|---|---|---|---|---|
| No. SNPs | OR | 95% CI | P-value | |
| (A) Direct causal effect of ADHD on AD, independent of EA | 6 | |||
| Inverse-variance weighted | 1.00 | 0.99, 1.01 | 0.76 | |
| MR-Egger | ||||
| Intercept | 0.99 | 0.99, 1.00 | 0.83 | |
| Estimate | 1.00 | 0.98, 1.01 | 0.70 | |
| (B) Direct causal effect of ADHD on AD, independent of IQ | 7 | |||
| Inverse-variance weighted | 1.00 | 0.99, 1.02 | 0.29 | |
| MR-Egger | ||||
| Intercept | 1.00 | 0.99, 1.00 | 0.73 | |
| Estimate | 1.00 | 0.98, 1.02 | 0.57 | |
SNP single nucleotide polymorphism, OR odds ratio, CI confidence intervals. Results are presented per log odds ratio increase of the exposure of interest.