Table 5.
Direct causal effects of genetic liability to ASD on Alzheimer’s disease, independent of (A) Educational Attainment (EA) (B) Intelligence (IQ).
| Causal effect estimates | ||||
|---|---|---|---|---|
| No. SNPs | OR | 95% CI | P-value | |
| (A) Direct causal effect of ASD on AD, independent of EA | 7 | |||
| Inverse-variance weighted | 0.99 | 0.98, 1.00 | 0.28 | |
| MR-Egger | ||||
| Intercept | 0.99 | 0.99, 1.00 | 0.60 | |
| Estimate | 0.99 | 0.98, 1.01 | 0.72 | |
| (B) Direct causal effect of ASD on AD, independent of IQ | 7 | |||
| Inverse-variance weighted | 0.99 | 0.98, 1.01 | 0.99 | |
| MR-Egger | ||||
| Intercept | 1.00 | 0.99, 1.00 | 0.13 | |
| Estimate | 0.98 | 0.96, 1.00 | 0.26 | |
SNP single nucleotide polymorphism, OR odds ratio, CI confidence intervals. Results are presented per log odds ratio increase of the exposure of interest.