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. 2022 Oct 1;12:16473. doi: 10.1038/s41598-022-20141-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The IgA1 CH1 region decreases ADCP and has little effect on ADCC in CAP88-CH06 antibodies. (a) ADCP activity of the CAP88-CH06 IgA1 WT, IgA1_IgG1CH1 and IgG1_IgA1CH1 antibodies was measured using THP-1 phagocytosis assay and the phagocytosis score shown as an area under the curve (AUC) measure. (b) ADCC activity of the CAP88-CH06 IgA1 WT, IgA1_IgG1CH1, IgG1 WT and IgG1_IgA1CH1 antibodies was measured using an infectious ADCC assay. The % killing activity is shown as an AUC measure. In all experiments, HIVIG, a polyclonal plasma cocktail from HIV-infected individuals, is used as a positive control and Palivizumab, a RSV-specific mAb, was used as a negative control. Experiments were conducted in duplicate and error bars represent the mean with standard deviation of two experiments. The Kruskal–Wallis test with Dunn’s correction was performed and no comparisons were significantly different except for the negative control, Palivizumab. Fold changes are shown in black.