Fig. 3. OTUD1 attenuates the resistance of NSCLC cells to erlotinib in vivo.

Mice were inoculated with PC-9/ER cells transduced with lentivirus carrying oe-OTUD1, or treated with oe-OTUD1 + erlotinib. A Representative images showing xenografts in mice. B Tumor volume of mice. C Tumor weight of mice. D TUNEL positive cells in the tumor tissues of mice. E IHC staining of Ki67 protein in the tumor tissues of mice. n = 10. ***p < 0.001. Data are shown as mean ± standard deviation. Data among multiple groups were analyzed by one-way ANOVA and Tukey’s multiple comparisons test. Bonferroni-corrected repeated measures ANOVA was applied for comparison of data at varied time points.