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. 2022 Oct 1;12:16477. doi: 10.1038/s41598-022-20684-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Backscattered SEM Images of Acp4^+/+, Acp4^+/R110C, and Acp4^R110C/R110C Mandibular Molars from D14 and 7-week Mice. (A) At D14 the mandibular first molars are very close to erupting into the oral cavity. The soft tissues have been removed to see the completed crown surface prior to potential post-eruptive changes. (B) The 7-week molars have been in function for about 5 weeks and feeding on a soft chow diet. (C) Close views of a 7-week Acp4^R110C/R110C mandibular first molar. The Acp4^+/+ and Acp4^+/R110C molars are indistinguishable. The cusps of D14 Acp4^R110C/R110C molars appear slender and pointed as the mineralized material covering them is much thinner than normal enamel. This layer of aplastic enamel is studded with small nodules that give the surface a rough appearance. The 7-week Acp4^R110C/R110C molars show severe attrition and dentin exposure due to the absence of a true enamel layer. Most mineralized nodules that appeared at D14 have been abraded or chipped away, while some remain on the tooth surface.