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. 2022 Oct 2;42:30. doi: 10.1186/s41232-022-00214-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Morphological characterization of 15 RECs. a Size distribution comparison between RECs (15 clones) and conventionally processed bulk MSCs (cMSCs, 9 lots) and their time-course changes. Only adherent and extending cells are counted. The dotted vertical line represents the average cell sizes. b Representative time-course images of REC and Bulk MSC. Yellow and blue arrows represent proliferating cells and proliferated cells in near time, respectively. c Size distribution and their time-course changes among 15 clones. d Correlation of “SD of area” and serial-passage limitation number. R² indicates the coefficient of determination. e, f PCA plot of 15 RECs profiled by 24 morphological descriptors. PCA plot with clone color labels (e). PCA plot colored by the heatmap of their serial-passage potencies (f)