Table 3.
Depletion of cysteine peptide measured by RapidFire-MS/MS method
| Sample Name | CASRN | IC50 (M) | Efficacy (% peptide depletion) |
|---|---|---|---|
| p-Benzoquinone | 106-51-4 | 4.84E-06 | −119.4 |
| (E)-2-Hexenal | 6728-26-3 | 5.58E-05 | −28.06 |
| (S)-4-Isopropenyl-1-cyclohexene-1-carboxaldehyde | 18031-40-8 | 1.16E-04 | −108.8 |
| 1-Butanola | 71-36-3 | Inactive | Inactive |
| 2,3-Butanedione | 431-03-8 | 4.11E-05 | −95.45 |
| 2-Mercaptobenzothiazole | 149-30-4 | 1.31E-04 | −97.27 |
| 2-Methyl-4-isothiazolin-3-one hydrochloride | 26172-54-3 | 3.63E-06 | −101.9 |
| 2-Propenoic acid, 2-methyl-, monoester with 1,2-propanedioa,* | 923-26-2 | Inactive | Inactive |
| 3-(Dimethylamino)propylaminea | 109-55-7 | Inactive | Inactive |
| 3,4-Dihydrocoumarin | 119-84-6 | 6.95E-05 | −56.7 |
| 4-Hydroxybenzoic acid | 99-96-7 | 1.27E-04 | −14.37 |
| 4-Methoxyacetophenone | 100-06-1 | Inactive | Inactive |
| 5-Chloro-2-methyl-3(2H)-isothiazolone | 26172-55-4 | 1.44E-05 | −122.3 |
| 6-Methyl coumarina | 92-48-8 | Inactive | Inactive |
| Benzisothiazolin-3-one | 2634-33-5 | 8.65E-07 | −110.5 |
| Benzoyl peroxide | 94-36-0 | 9.53E-05 | −107 |
| Benzyl alcohola | 100-51-6 | Inactive | Inactive |
| Benzyl benzoatea | 120-51-4 | Inactive | Inactive |
| Benzylideneacetone | 122-57-6 | 2.12E-005 | 97.67 |
| Chlorobenzenea | 108-90-7 | Inactive | Inactive |
| Cinnamic aldehyde | 104-55-2 | 1.05E-03 | −124.4 |
| Cyclamen aldehyde | 103-95-7 | 2.91E-05 | −14.77 |
| Diethyl maleate | 141-05-9 | 3.00E-04 | −108 |
| Diethyl phthalatea | 84-66-2 | Inactive | Inactive |
| Dimethyl isophthalatea | 1459-93-4 | Inactive | Inactive |
| Dinitrochlorobenzene | 97-00-7 | 3.19E-04 | −198.8 |
| Diphenylcyclopropenone | 886-38-4 | 2.38E-05 | −43.84 |
| Dodecyl gallatea,* | 1166-52-5 | Inactive | Inactive |
| Ethyl acrylatea,* | 140-88-5 | Inactive | Inactive |
| Ethylene glycol dimethacrylateb | 97-90-5 | N/A | −60.29 |
| Farnesalb | 19317-11-4 | N/A | −17.4 |
| Formaldehydeb | 50-00-0 | N/A | −11.6 |
| Glutaraldehyde | 111-30-8 | 1.03E-03 | −119.3 |
| Glycerola | 56-81-5 | Inactive | Inactive |
| Hexyl cinnamic aldehydea | 165184-98-5 | Inactive | Inactive |
| Hydroxycitronellala | 107-75-5 | Inactive | Inactive |
| Hydroxyethyl acrylate | 818-61-1 | 5.82E-05 | −132.1 |
| Imidazolidinyl ureaa,* | 39236-46-9 | Inactive | Inactive |
| Lactic acida | 50-21-5 | Inactive | Inactive |
| m-Aminophenol | 591-27-5 | 8.66E-06 | −26.38 |
| Methyl 2-nonynoate | 111-80-8 | 3.51E-04 | −39.99 |
| Methyl salicylatea | 119-36-8 | Inactive | Inactive |
| Methyldibromo glutaronitrile | 35691-65-7 | 1.01E-06 | −102.5 |
| n-Hexanea | 110-54-3 | Inactive | Inactive |
| Octanoic acid | 124-07-2 | 3.31E-04 | −25.36 |
| Oxalic acida | 144-62-7 | Inactive | Inactive |
| Oxazolone | 15646-46-5 | 9.09E-06 | −95.43 |
| Palmitoyl chloridea,* | 112-67-4 | Inactive | Inactive |
| Penylcinnamaldehyde | 122-40-7 | 2.92E-04 | −104.8 |
| Phenylacetaldehydea,* | 122-78-1 | Inactive | Inactive |
| Phthalic anhydridea | 85-44-9 | Inactive | Inactive |
| Propyl parabena | 94-13-3 | Inactive | Inactive |
| Protectol PP (Lilial) | 80-54-6 | 3.58E-05 | −15.36 |
| Trimellitic anhydridea | 552-30-7 | Inactive | Inactive |
| Vinyl pyridinea | 100-69-6 | Inactive | Inactive |
a
Inactive indicated no concentration-response inhibition.
b
N/A indicates the curve is too wide to calculate IC50, and efficacy values are the span of % peptide depletion between the lowest and highest concentrations of compound treatment.
*
False negative compounds